PROTAC SGK3 degrader-1

SKU T13847-1 mL * 10 mM (in DMSO) Category PROTAC Brand: TargetMol

Price range: 62 CAD through 4,752 CAD

Size

1 mg 1 mL * 10 mM (in DMSO)25 mg 5 mg 50 mg

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Products Details

Product Description

– PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]

Web ID

– T13847

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C57H73FN10O11S2

References

– Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

CAS Number

– 2381320-35-8

Molecular Weight

– C57H73FN10O11S2

SMILES

– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCCCCCN2CCO[C@@H](COc3nc(nc4[nH]ncc34)-c3ccc(NS(=O)(=O)c4cc(C)ccc4F)cc3)C2)C(C)(C)C)cc1

Target

– Others

Pathway

– PROTAC|||Metabolism

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.