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PROTAC PD-1/PD-L1 degrader-1
Price range: 405 CAD through 5,968 CAD
Products Details
Product Description
– PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
Web ID
– T40112
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C59H58ClN7O11
References
– Cheng B,et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-LEur J Med Chem. 2020;199:112377.
CAS Number
– 2447066-37-5
Molecular Weight
– C59H58ClN7O11
Compound Purity
– 0.9907
SMILES
– N#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(Cl)C=C2CN6CCCCC6C(=O)N7CCN(C(=O)CCCC(=O)NC8=CC=CC=9C(=O)N(C(=O)C89)C%10C(=O)NC(=O)CC%10)CC7
Pathway
– Cell Cycle/Checkpoint|||Apoptosis|||PROTAC|||Immunology/Inflammation
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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