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PROTAC ERRα Degrader-3
$300 – $2,250
Products Details
Product Description
– PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins[1].
Web ID
– HY-139185
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C47H50F6N6O7S
References
– [1]Lijie Peng, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772.
CAS Number
– 2306388-65-6
Molecular Weight
– 956.99
Compound Purity
– 98.82
SMILES
– COC(C=C1/C=C(C#N)/C(NCCCCC(N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O)=C(C=C1)OCC5=C(C=C(C=C5)C(F)(F)F)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 80 mg/mL (ultrasonic)
Target
– Estrogen Receptor/ERR;PROTACs
Isoform
– ERRα;von Hippel-Lindau (VHL)
Pathway
– PROTAC;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
