PROTAC EGFR degrader 11
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PROTAC EGFR degrader 11

SKU T88077-10 mg Category Brand:

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Products Details

Product Description

– PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.

Web ID

– T88077

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C49H64ClFN10O7S

CAS Number

– 3034244-71-5

Molecular Weight

– C49H64ClFN10O7S

SMILES

– O=C1NC(=O)C(C2=CC=C(C=C2F)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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