PROTAC CDK9 degrader-11
Add to CompareAdded to Compare

Download Files:

PROTAC CDK9 degrader-11

SKU T205652-10 mg Category Brand:

This product is currently out of stock and unavailable.

Request Pricing

Products Details

Product Description

– PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)

Web ID

– T205652

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C39H48Cl2N10O5

CAS Number

– 3039540-19-4

Molecular Weight

– C39H48Cl2N10O5

SMILES

– O=C(NC1=CNN=C1C(=O)NC2CCN(C(=O)CN3CCC(CN4CCN(C=5C=CC=C(C5)NC6C(=O)NC(=O)CC6)CC4)CC3)CC2)C=7C(Cl)=CC=CC7Cl

Target

– Others

Pathway

– PROTAC|||Cell Cycle/Checkpoint

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
FKBP12 PROTAC dTAG-13
FKBP12 PROTAC dTAG-13 Price range: 118 CAD through 261 CAD
1 mg25 mg5 mg

1000 in stock

Select options
Duocarmycin TM
Duocarmycin TM Price range: 253 CAD through 2,048 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
CDK9-IN-11
CDK9-IN-11 Price range: 2,432 CAD through 4,000 CAD
100 mg25 mg50 mg

1000 in stock

Select options
PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 Price range: 730 CAD through 1,984 CAD
1 mg10 mg5 mg

1000 in stock

Add to cart
N-Boc-4-hydroxy-L-proline methyl ester
N-Boc-4-hydroxy-L-proline methyl ester 46 CAD

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });