Propargyl-PEG4-acid
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Propargyl-PEG4-acid

SKU T16614-100 mg Category Brand:

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Product Description

– Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

Web ID

– T16614

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C12H20O6

References

– Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

CAS Number

– 1415800-32-6

Molecular Weight

– C12H20O6

SMILES

– C(OCCOCCOCC#C)COCCC(O)=O

Target

– Others

Pathway

– Others

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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