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Products Details
Product Description
– Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].
Web ID
– HY-17463S
Shipping
– Room temperature
Molecular Formula
– C21H20D8O5
References
– [1]Prednisolone. J Am Pharm Assoc. 1976;16(3):143-146.|[2]Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 368.49
SMILES
– C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([2H])[C@@]([C@H](C1([2H])[2H])O)([2H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])=C4)=O)C
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Glucocorticoid Receptor
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
