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Prazosin (hydrochloride)
$66 – $190
Products Details
Product Description
– Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders[1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively[3].
Web ID
– HY-B0193A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H22ClN5O4
Citations
– BMC Pulm Med. 2021 Jun 5;21(1):189.|Cell Discov. 2023 Feb 7;9(1):16.|J Exp Med. 2023 Nov 6;220(11):e20230577.|J Transl Med. 2022 Oct 2;20(1):444.|Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3.|Biomed Pharmacother. 2020 Apr;124:109731.|Cells. 2023 May 24, 12(11), 1461.|J Med Chem. 2021 Mar 11;64(5):2725-2738.
References
– [1]Dennis D Rasmussen, et al. The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72.|[2]W S Colucci, et al. Nonlinear relationship between alpha 1-adrenergic receptor occupancy and norepinephrine-stimulated calcium flux in cultured vascular smooth muscle cells.Mol Pharmacol. 1985 May;27(5):517-24.|[3]Deborah L White, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.Blood. 2006 Jul 15;108(2):697-704.|[4]Jing Zhang, et al. Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway. Exp Ther Med. 2020 Aug;20(2):1145-1152.
CAS Number
– 19237-84-4
Molecular Weight
– 419.86
Compound Purity
– 99.93
SMILES
– O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : 14.29 mg/mL (ultrasonic)|H2O : 0.59 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Autophagy
Isoform
– α adrenergic receptor
Pathway
– Autophagy;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
