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PPY-A
$488 – $780
Products Details
Product Description
– PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba⁄F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].
Web ID
– HY-12083
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H20N4O2
References
– [1]Tianjun Zhou, et al. Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des. 2007 Sep;70(3):171-81.
CAS Number
– 875634-01-8
Molecular Weight
– 372.42
SMILES
– O=C(C1=CC(C2=CN=C(NC=C3C4=CC=CC=C4OC)C3=C2)=CN=C1)N(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcr-Abl
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
