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Ponatinib-d8
$340
Only 1000 item(s) left in stock.
Products Details
Product Description
– Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Web ID
– HY-12047S
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H19D8F3N6O
References
– [1]O’Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412.
CAS Number
– 1562993-37-6
Molecular Weight
– 540.61
Compound Purity
– 99.91
SMILES
– O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Bcr-Abl;FGFR;PDGFR;Src;VEGFR
Isoform
– FGFR1;PDGFRα;VEGFR2/KDR/Flk-1
Pathway
– Autophagy;Protein Tyrosine Kinase/RTK
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
