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Products Details
Product Description
– Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
Web ID
– HY-123324
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H11N3O5
References
– [1]Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501.
CAS Number
– 1547162-41-3
Molecular Weight
– 289.24
SMILES
– O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
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