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Polyinosinic-polycytidylic acid (sodium)
$109 – $300
Products Details
Product Description
– Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis[1][2].
Web ID
– HY-135748
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– (C10H13N4O8P)x.(C9H14N3O8P)x.xNa
Citations
– Adv Funct Mater. 29 August 2022.|Liver Int. 2022 Oct 17.|Mol Ther Oncolytics. 25 August 2022.|Phytomedicine. 2021, 153495.|SSRN. 2021 Apr 26.|Cancer Med. 2023 Jun 7.|Chem Eng J. 2021 Aug 15;418:129392.|SSRN. 2023 Apr 29.|Virol Sin. 2023 Aug 24;S1995-820X(23)00104-9.|Virol Sin. 2023 May 2;S1995-820X(23)00048-2.
References
– [1]Besch R, et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest. 2009 Aug;119(8):2399-411.|[2]Cheng YS, et al. Anticancer function of polyinosinic-polycytidylic acid. Cancer Biol Ther. 2010 Dec 15;10(12):1219-23.|[3]Robert Field, et al. Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun. 2010 Aug;24(6):996-1007.
CAS Number
– 42424-50-0
Molecular Weight
– N/A
Compound Purity
– 99.0
SMILES
– O[C@H]1[C@@H](O[C@H](COP(O)(O)=O)[C@H]1O)N2C3=C(C(NC=N3)=O)N=C2.O[C@H]4[C@H](N5C(N=C(N)C=C5)=O)O[C@H](COP(O)(O)=O)[C@H]4O.[x].[x].[Na].[x]
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– H2O : 10 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Toll-like Receptor (TLR)
Isoform
– TLR3
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
