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PLX-3618
Price range: 2,432 CAD through 4,000 CAD
Products Details
Product Description
– PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models.
Web ID
– T88470
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C32H27N9O2S
CAS Number
– 2851986-76-8
Molecular Weight
– C32H27N9O2S
SMILES
– CC=1C2=C(N3C([C@H](CC(N)=O)N=C2C4=CC=C(C=C4)C5=CC(NC(=O)C6=C7N(N=C6)C=CC=N7)=CC=C5)=NN=C3C)SC1C
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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