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Products Details
Product Description
– Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization[1].
Web ID
– HY-W748509
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H27NO3
References
– [1]Lee W, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013 Jan 4;430(1):406-12..
CAS Number
– 88660-10-0
Molecular Weight
– 341.44
SMILES
– O=C(N1CCCCC1)/C=C/CCCC/C=C/C2=CC=C(OCO3)C3=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis, Caspase
Pathway
– Apoptosis
Product type
– Reference compound
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