Pinometostat
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Pinometostat

SKU T3099-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 130 CAD

Products Details

Product Description

– Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor (Ki=80 pM). Pinometostat has antitumor activity and can be used in experiments to study a variety of leukemia treatments.

Web ID

– T3099

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H42N8O3

Citations

– 1. Yu S, Zhou C, He J, et al. BMP4 drives primed to naïve transition through PGC-like state. Nature Communications. 2022, 13(1): 1-15 2. Chen R, Xie W, Cai B, et al. Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs). Stem Cells International. 2018 Dec 25;2018:5965727 3. Zhao X, Li X, Sun H, et al.Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.Nucleic Acids Research.2023: gkad640. 4. Ma Z, Huang X, Kuang J, et al.Cpt1a Drives primed-to-naïve pluripotency transition through lipid remodeling.Communications Biology.2024, 7(1): 1223.

References

– Robert A. Protein methyltransferases in cancer. AACR Annual Meeting, 2013.

CAS Number

– 1380288-87-8

Molecular Weight

– C30H42N8O3

Compound Purity

– 0.9986

SMILES

– O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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