Download Files:
Pimelic Diphenylamide 106
$50 – $440
Products Details
Product Description
– Pimelic Diphenylamide 106 is a slow, tight-binding class I HDAC inhibitor (inhibits HDAC1, 2, and 3, IC50 values 150 nM, 760 nM, and 370 nM, respectively) with no activity against class II HDACs.
Web ID
– HY-19348
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H25N3O2
References
– [1]Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.|[2]Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.
CAS Number
– 937039-45-7
Molecular Weight
– 339.43
Compound Purity
– 98.39
SMILES
– O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– HDAC
Isoform
– HDAC1;HDAC2;HDAC3;HDAC8
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
