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Product Description
– Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
Web ID
– HY-16702
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H16N2S
Citations
– FASEB J. 2021 Feb;35(2):e21325.|Front Cell Dev Biol. 2020 Jul 29;8:703.|Front Immunol. 2020 Feb 20;8:75.|Front Mol Biosci. 2021 Aug 19;8:697457.|Int J Mol Med. 2021 May 7.|Int J Mol Sci. 2023 Jul 17, 24(14), 11554.|PLoS One. 2018 Sep 20;13(9):e0203833. |Blood Cells Mol Dis. 2024, Jan, 104, 102798.|Cancer Cell Int. 2023 Sep 28;23(1):221.|Cell Biol Toxicol. 2022 Jan 13.|Cell Commun Signal. 2022 Sep 5;20(1):96.|Life Sci. 2021 Jun 7;280:119698.
References
– [1]Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.|[2]Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.|[3]Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.
CAS Number
– 60477-34-1
Molecular Weight
– 268.38
SMILES
– CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
