Pifithrin-α hydrobromide
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Pifithrin-α hydrobromide

SKU T2707-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 701 CAD

Products Details

Product Description

– Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.

Web ID

– T2707

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H18N2OS·HBr

Citations

– 1. Chen L, Zhang L, Jin G, et al.Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling.Cell Reports.2023, 42(8). 2. Lin X, Lin T, Wang X, et al.Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids.Phytomedicine.2023: 155109. 3. Wu Y, Zhou T, Qian D, et al.Z-Guggulsterone Induces Cell Cycle Arrest and Apoptosis by Targeting the p53/CCNB1/PLK1 Pathway in Triple-Negative Breast Cancer.ACS Omega.2023 4. Hussain M, Lu Y, Tariq M, et al. A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism. Iscience. 2022, 25(7): 104591. 5. Yang R, Yang H, Wei J, et al. Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach. Frontiers in Pharmacology. 2021: 2839. 6. Wu X, Han C, Wang L, et al. Iron increases the susceptibility of colorectal cancer cells to compound Kushen Injection via the decrease of TOP2A and p53. Pharmacological Research-Modern Chinese Medicine. 2022, 2: 100058. 7. Luo Y, Gao X, Zou L, et al. Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative Medicine and Cellular Longevity. 2021 8. Guo Y, Li Q, Zhao G, et al. Loss of TRIM31 promotes breast cancer progression through regulating K48-and K63-linked ubiquitination of p53. Cell Death & Disease. 2021, 12(10): 1-13. 9. Shang Y, Zhang S, Cheng Y, et al. Tetrabromobisphenol a exacerbates the overall radioactive hazard to zebrafish (Danio rerio). Environmental Pollution. 2022: 120424. 10. Jiang W, Wang X, Su S, et al. Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics. Bioengineered. 2022, 13(4): 9839-9854

References

– Komarov PG, et al. Science, 1999, 285(5434), 1733-1737.

CAS Number

– 63208-82-2

Molecular Weight

– C16H18N2OS·HBr

Compound Purity

– 0.9817

SMILES

– Br.Cc1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N

Pathway

– Immunology/Inflammation|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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