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Products Details
Product Description
– PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research[1].
Web ID
– HY-147898
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H21BrN6O2
References
– [1]Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051.
CAS Number
– 2458163-92-1
Molecular Weight
– 493.36
SMILES
– BrC1=CC(/C=N/NC2=NC(N3CCOCC3)=C(C(C4=CC=C(C=C4)OC)=N2)C#N)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PI3K
Isoform
– PI3Kα;PI3Kβ;PI3Kδ
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
