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PI3Kδ-IN-15
Price range: 48 CAD through 309 CAD
Products Details
Product Description
– PI3Kδ-IN-15 is a selective PI3Kδ inhibitor that inhibits PI3Kδ more than 30-fold more effectively than PI3Kγ, PI3Kβ, and PI3Kα.
Web ID
– T8651
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H16FN7O
Citations
– 1. Zhang X, Dai Q, Shan J, et al.Inhibition of phosphoinositide‑3 kinases γ/δ ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model.Experimental and Therapeutic Medicine.2023, 25(5): 1-11.
2. Zhang S, Shan J, Jie Y, et al.Inhibition of PI3K p110δ rebalanced Th17/Treg and reduced macrophages pyroptosis in LPS-induced sepsis.Molecular Immunology.2024, 170: 110-118.
References
– Brian J Lannutti, Sarah A Meadows, Sarah E M Herman,et al.CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood. 2011 Jan 13;117(2):591-4.
CAS Number
– 1146702-54-6
Molecular Weight
– C21H16FN7O
Compound Purity
– 0.9961
SMILES
– [C@H](NC1=C2C(N=CN2)=NC=N1)(C)C=3N(C(=O)C=4C(N3)=CC=CC4F)C5=CC=CC=C5
Pathway
– PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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