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Products Details
Product Description
– PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC50 of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models[1].
Web ID
– HY-144254
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H16ClN9
References
– [1]Qi J, Wang W, Tang Y, et al. Discovery of Novel Indazoles as Potent and Selective PI3Kδ Inhibitors with High Efficacy for Treatment of Hepatocellular Carcinoma. J Med Chem. 2022;65(5):3849-3865.
CAS Number
– 2409725-49-9
Molecular Weight
– 405.84
SMILES
– N#CC1=C(N[C@H](C2=NN(C3=CC=CN=C3)C4=C2C=CC(Cl)=C4)C)N=C(N)N=C1N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Apoptosis;PI3K
Isoform
– PI3Kδ
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
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