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Physcion
$35 – $330
Products Details
Product Description
– Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].
Web ID
– HY-N0108
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H12O5
References
– [1]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.|[2]Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.
CAS Number
– 521-61-9
Molecular Weight
– 284.26
Compound Purity
– 99.10
SMILES
– O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– Acetone : < 1 mg/mL|DMF : 1 mg/mL (ultrasonic)|DMSO : 3.33 mg/mL (ultrasonic;warming;adjust pH to 9 with NaOH;heat to 60°C)|Ethanol : < 1 mg/mL|Methanol : < 1 mg/mL (ultrasonic)|THF : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Natural Products
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