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Phenylephrine
$50 – $55
Products Details
Product Description
– (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.
Web ID
– HY-B0769
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C9H13NO2
Citations
– Biochim Biophys Acta Mol Basis Dis. 2023 Aug 27;166859.|BMC Pulm Med. 2021 Jun 5;21(1):189.|J Cardiovasc Pharmacol. 2022 Sep 1;80(3):430-441.|J Endod. 2023 Sep 26:S0099-2399(23)00608-8.|Mol Med Rep. July 6, 2021.|Sci Rep. 2023 Oct 2;13(1):16550.|Front Cardiovasc Med. 2021 Jun 16;8:679240.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227.
References
– [1]Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.|[2]Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.|[3]Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.|[4]Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.|[5]Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.
CAS Number
– 59-42-7
Molecular Weight
– 167.21
Compound Purity
– 99.52
SMILES
– O[C@H](C1=CC(O)=CC=C1)CNC
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic)
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
