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Phenformin (hydrochloride)

SKU HY-16397A-1 g Category Reference compound Tags AMPK;Autophagy, Autophagy;Epigenetics;PI3K/Akt/mTOR, Cancer

$35 – $80

Size1 g

1 g 5 g 10mM/1mL 500 mg

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$50

Only 1000 item(s) left in stock.

Products Details

Product Description

– Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.

Web ID

– HY-16397A

Storage Temperature

– 4°C (Powder, stored under nitrogen)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C10H16ClN5

References

– [1]Sakamoto K, et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab.?2004 Aug;287(2):E310-7.|[2]Zhang L, et al. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66.|[3]Woollhead AM, et al. Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol. 2005 Aug 1;566(Pt 3):781-92. Epub 2005|[4]Dilman VM, et al. Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch. 1978;48(1):1-8.|[5]Moreira AL, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med. 1993 Jun 1;177(6):1675-80.

CAS Number

– 834-28-6

Molecular Weight

– 241.72

Compound Purity

– 99.29

SMILES

– NC(NC(NCCC1=CC=CC=C1)=N)=N.Cl

Clinical Information

– Launched

Research Area

– Cancer

Solubility

– DMF : 1 mg/mL (ultrasonic)|DMSO : 1 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl)|Ethanol : 2 mg/mL (ultrasonic)|H2O : 12.5 mg/mL (ultrasonic)

Target

– AMPK;Autophagy

Isoform

– AMPK

Pathway

– Autophagy;Epigenetics;PI3K/Akt/mTOR

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.