PG01
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PG01

SKU T16516-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 122 CAD through 2,160 CAD

Products Details

Product Description

– PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.

Web ID

– T16516

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H29N3O2

References

– Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67(5):1797-807.

CAS Number

– 853138-65-5

Molecular Weight

– C28H29N3O2

Compound Purity

– 0.9987

SMILES

– CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1

Target

– Drug-Linker Conjugates for ADC

Pathway

– Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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