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PFK-015
$66 – $726
Products Details
Product Description
– PFK-015, a derivative of 3PO, is a specific PFKFB3 inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. PFK-015 can be used for the research of multiple cancers such as lung cancer, stomach cancer, colon cancer and esophageal squamous cell carcinoma (ESCC)[1][2].
Web ID
– HY-12204
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H12N2O
References
– [1]Jia Bo Zheng, et al. Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer. Oncoimmunology. 2022 May 25;11(1):2079182. |[2]Brian Clem, et al. Characterization of a novel small molecule antagonist of 6-phosphofructo-2-kinase that suppresses glucose metabolism and tumor growth. ORAL PRESENTATIONS – PROFFERED ABSTRACTS| APRIL 15 2011.
CAS Number
– 4382-63-2
Molecular Weight
– 260.29
Compound Purity
– 98.29
SMILES
– O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC=CC=C3C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– DMSO : 25.2 mg/mL (ultrasonic;warming)
Target
– Autophagy
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
