PF-543
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PF-543

SKU T6085-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 74 CAD through 1,522 CAD

Products Details

Product Description

– PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 of 2.0 nM and Ki of 3.6 nM.

Web ID

– T6085

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H31NO4S

Citations

– 1. Wen M, Sun X, Pan L, et al.Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-κB pathway.European Journal of Pharmacology.2024: 176799.

References

– Schnute ME, et al. Biochem J, 2012, 444(1), 79-88.

CAS Number

– 1415562-82-1

Molecular Weight

– C27H31NO4S

Compound Purity

– 0.9929

SMILES

– Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1

Pathway

– Apoptosis|||Autophagy|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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