PF-3644022
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PF-3644022

SKU T16501-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 50 CAD through 2,800 CAD

Products Details

Product Description

– PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively).

Web ID

– T16501

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H18N4OS

References

– Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807

CAS Number

– 1276121-88-0

Molecular Weight

– C21H18N4OS

Compound Purity

– 0.9912

SMILES

– C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccc(C)nc2)C(=O)N1

Target

– Others

Pathway

– MAPK|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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