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PF-06751979
$390 – $2,750
Products Details
Product Description
– PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
Web ID
– HY-112157
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C18H19F2N5O3S2
References
– [1]O’Neill BT, et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61(10):4476-4504.
CAS Number
– 1818339-66-0
Molecular Weight
– 455.50
Compound Purity
– 99.23
SMILES
– FC(F)OC1=CN=C(C(NC2=CSC([C@]34CO[C@@H](C)C[C@@]3([H])CSC(N)=N4)=N2)=O)C=C1
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– DMSO : 150 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)
Target
– Beta-secretase
Isoform
– BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
