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Pemetrexed disodium hemipenta hydrate
Price range: 53 CAD through 187 CAD
Products Details
Product Description
– Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.
Web ID
– T6226
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H21N5O6·2Na·5/2H2O
Citations
– 1. Bi G, Liang J, Zhao M, et al. MiR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma by targeting CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways. Molecular Therapy-Nucleic Acids. 2022
2. Zhao G, Liang J, Shan G, et al.KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.Communications Biology.2023, 6(1): 570.
3. Zhao G, Liang J, Zhang Y, et al.MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity by suppressing SAT1.Communications Biology.2024, 7(1): 680.
References
– Shih C, et al. Cancer Res. 1997, 57(6), 1116-1123.
CAS Number
– 357166-30-4
Molecular Weight
– C20H21N5O6·2Na·5/2H2O
Compound Purity
– 0.9876
SMILES
– O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1.Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
Pathway
– Apoptosis|||Autophagy|||Metabolism|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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