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PD176252
$77 – $495
Products Details
Product Description
– PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
Web ID
– HY-103286
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H36N6O5
References
– [1]Ashwood V, et al. PD 176252–the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94.|[2]Schepetkin IA, et al. Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol. 2011 Jan;79(1):77-90.|[3]Moody TW, et al. Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. Eur J Pharmacol. 2003 Aug 1;474(1):21-9.
CAS Number
– 204067-01-6
Molecular Weight
– 584.67
Compound Purity
– 99.18
SMILES
– O=C(NC1=CC=C([N+]([O-])=O)C=C1)N[C@](CC2=CNC3=C2C=CC=C3)(C)C(NCC4(C5=CC=C(OC)C=N5)CCCCC4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 115 mg/mL (ultrasonic)
Target
– Bombesin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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