PD146176
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PD146176

SKU T7530-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 66 CAD through 771 CAD

Products Details

Product Description

– PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

Web ID

– T7530

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H11NS

References

– Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.

CAS Number

– 4079-26-9

Molecular Weight

– C15H11NS

Compound Purity

– 0.9977

SMILES

– C1Sc2ccccc2-c2[nH]c3ccccc3c12

Pathway

– Autophagy|||Apoptosis|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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