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Products Details
Product Description
– PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].
Web ID
– HY-155740
Shipping
– Room temperature
Molecular Formula
– C29H25ClFN3O3
References
– [1]Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2′-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603.
CAS Number
– 2765535-21-3
Molecular Weight
– 517.98
SMILES
– N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)Cl)=C2)CNCCO)=CN=C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
