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PD-1/PD-L1-IN-29
$350 – $1,450
Products Details
Product Description
– PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity[1].
Web ID
– HY-152240
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H24N2O6
References
– [1]Chengliang Sun, et al. Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment. J Med Chem. 2022 Dec 29.
CAS Number
– 2665734-13-2
Molecular Weight
– 460.48
Compound Purity
– 99.96
SMILES
– OC[C@H](NCC1=CC2=C(C=C1OC)C(N(C2=O)C3=C(C(C4=CC=CC=C4)=CC=C3)C)=O)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 66.67 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl)
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
