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Products Details
Product Description
– PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].
Web ID
– HY-146740
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C44H35NO6
References
– [1]Zhang M, et al. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022; 54:116579.
CAS Number
– 2891831-47-1
Molecular Weight
– 673.75
SMILES
– CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C(OC4=CC(OC5=C4C=CC6=C5C=CC=C6)=O)=C3)CN7CC8=C(C[C@@H]7C(O)=O)C=CC=C8
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
