Download Files:
Products Details
Product Description
– PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia[1].
Web ID
– HY-153451
Shipping
– Room temperature
Molecular Formula
– C22H28N6O2S2
References
– [1]Serrano-Wu MH, et al. Preparation of 2-[[2-methyl-3-[[5-(methylthio)pyrimidin-2-yl]amino]propyl]amino]benzo[d]thiazoles and analogs as PCSK9 inhibitors and methods of their use. World Intellectual Property Organization, WO2020150474 A1. 2020-07-23.
CAS Number
– 2455423-94-4
Molecular Weight
– 472.63
SMILES
– O=C(N1CCC(CC1)O)C2=CC=C(N=C(S3)NC[C@@H](C)CNC4=NC=C(SC)C=N4)C3=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
