Paquinimod
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Paquinimod

SKU T7310-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 757 CAD

Products Details

Product Description

– Paquinimod (ABR 25757) is a S100A9 inhibitor preventing S100A9 binding to TLR-4.

Web ID

– T7310

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H22N2O3

Citations

– 1. Guo Q, Zhao Y, Li J, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host & Microbe. 2020 2. Jiang H, Zhao Y, Su M, et al.A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.Pharmacological Research.2023: 107029. 3. Liang L, Yang X, Zeng H, et al.S100A9-TLR4 axis aggravates dry eye through the blockage of autophagy.Experimental Eye Research.2024: 110052. 4. Shou C, Sun Y, Zhang Q, et al.S100A9 Inhibition Mitigates Acute Pancreatitis by Suppressing RAGE Expression and Subsequently Ameliorating Inflammation.Inflammation.2024: 1-12.

References

– Lee JU, et al. Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund’s Adjuvant. Can Respir J. 2021 Mar 15;2021:8896108.

CAS Number

– 248282-01-1

Molecular Weight

– C21H22N2O3

Compound Purity

– 0.9762

SMILES

– CCN(C(=O)c1c(O)c2c(CC)cccc2n(C)c1=O)c1ccccc1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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