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p-MPPI (hydrochloride)
$64 – $480
Products Details
Product Description
– p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
Web ID
– HY-120738
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H28ClIN4O2
References
– [1]Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep–waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.|[2]Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
CAS Number
– 220643-77-6
Molecular Weight
– 578.87
Compound Purity
– 99.81
SMILES
– O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 17.86 mg/mL (ultrasonic)|H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– 5-HT Receptor
Isoform
– 5-HT1 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
