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Ouabain (Octahydrate)
$66 – $95
Products Details
Product Description
– Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used for the treatment of congestive heart failure.
Web ID
– HY-B0542
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H60O20
References
– [1]Kobayashi M, et al. The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. PLoS One. 2017 May 11;12(5):e0176676.|[2]Venugopal J, et al. Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells. Exp Cell Res. 2017 Jun 15;355(2):142-152.|[3]Lima DB, et al. Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice. Oncol Lett. 2016 Dec;12(6):5275-5280.|[4]Meng L, et al. Ouabain induces apoptosis and autophagy in Burkitt’s lymphoma Raji cells. Biomed Pharmacother. 2016 Dec;84:1841-1848.
CAS Number
– 11018-89-6
Molecular Weight
– 728.77
Compound Purity
– 99.96
SMILES
– OC[C@@]([C@](CC1)(C[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]2O)([H])[C@@H]2O)C3)O)([C@@H]3O)[C@]([C@@H](C[C@@]45C)O)([H])[C@]1([H])[C@]4(CC[C@@H]5C(CO6)=CC6=O)O.[8 H2O]
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 125 mg/mL|H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy;Na+/K+ ATPase
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
