Ouabain octahydrate
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Ouabain octahydrate

SKU T1318-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 59 CAD through 114 CAD

Products Details

Product Description

– Ouabain octahydrate (Acocantherine) is a cardiac glycoside that inhibits Na(+)/K(+) ATPase. Ouabain octahydrate regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.

Web ID

– T1318

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H44O12·8H2O

Citations

– 1. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. 2. Geng X, Wang F, Tian D, et al Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction. Biochemical Pharmacology. 2020: 114226

References

– Kobayashi M, et al. The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. PLoS One. 2017 May 11;12(5):e0176676.

CAS Number

– 11018-89-6

Molecular Weight

– C29H44O12·8H2O

Compound Purity

– 0.9985

SMILES

– O.O.O.O.O.O.O.O.CC1OC(OC2CC(O)C3(CO)C4C(O)CC5(C)C(CCC5(O)C4CCC3(O)C2)C2=CC(=O)OC2)C(O)C(O)C1O

Target

– Reactive Oxygen Species|||Estrogen/progestogen Receptor

Pathway

– Autophagy|||Membrane transporter/Ion channel

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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