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OTSSP167 (hydrochloride)
$100 – $750
Products Details
Product Description
– OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.
Web ID
– HY-15512A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H29Cl3N4O2
Citations
– Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. |Elife. 2017 Mar 24;6:e24179.|Elife. 2018 Feb 8;7:e32838. |EMBO Mol Med. 2018 Mar;10(3). pii: e8274.|Free Radic Biol Med. 2021 Jun 15;S0891-5849(21)00377-4.|Gynecol Oncol. 2017 Apr;145(1):159-166.|Harvard Medical School LINCS LIBRARY|Neuro Oncol. 2020 Jan 11;22(1):58-69. |Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11. |Blood Cancer J. 2019 Nov 18;9(12):87.|Int J Oncol. 2022 Jul;61(1):89.|Mol Cancer. 2014 May 4;13:100.|Oncotarget. 2016 Feb 2;7(5):6266-80. |Oncotarget. 2017 Dec 20;9(2):2591-2602. |Patent. US20160291017A1.|PLoS One. 2017 Feb 24;12(2):e0172832. |Sci Rep. 2017 Feb 14;7:42502.
References
– [1]Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.|[2]Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11.|[3]Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.|[4]Meel MH, et al. MELK inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2018 Jul 30. pii: clincanres.0924.2018.|[5]Jurmeister S, et al. Identification of potential therapeutic targets in prostate cancer through a cross-species approach. EMBO Mol Med. 2018 Feb 5. pii: e8274.
CAS Number
– 1431698-10-0
Molecular Weight
– 523.88
Compound Purity
– 99.84
SMILES
– ClC1=CC(C2=CC=C(N=CC(C(C)=O)=C3N[C@H]4CC[C@H](CN(C)C)CC4)C3=N2)=CC(Cl)=C1O.[H]Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)
Target
– MELK
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
