OSMI-1
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OSMI-1

SKU T16409-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 878 CAD

Products Details

Product Description

– OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.

Web ID

– T16409

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H25N3O6S2

Citations

– 1. Wang N, Yu M, Fu Y, et al. Blocking ATM Attenuates SKOV3 Cell Proliferation and Migration by Disturbing OGT/OGA Expression via hsa-miR-542-5p. Frontiers in Oncology. 2022.12 2. Liu R, Liu Y, Zhang W, et al.PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma.Genes & Diseases.2023: 101114. 3. Wang J, Aniwan A, Liu H, et al.O-GlcNAcylation regulates HIF-1α and induces mesothelial-mesenchymal transition and fibrosis of human peritoneal mesothelial cells.Heliyon.2023

References

– Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.

CAS Number

– 1681056-61-0

Molecular Weight

– C28H25N3O6S2

Compound Purity

– 0.9983

SMILES

– COc1ccccc1C(NS(=O)(=O)c1ccc2[nH]c(=O)ccc2c1)C(=O)N(Cc1ccco1)Cc1cccs1

Target

– Others

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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