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Oleuropein
$55 – $390
Products Details
Product Description
– Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
Web ID
– HY-N0292
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H32O13
References
– [1]Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376.|[2]Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.
CAS Number
– 32619-42-4
Molecular Weight
– 540.51
Compound Purity
– 99.05
SMILES
– OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=CC)([H])O1
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)|H2O : ≥ 20 mg/mL
Target
– Apoptosis;Cytochrome P450;PPAR
Isoform
– CYP19;PPARγ
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
