NVP-2
Add to CompareAdded to Compare

Download Files:

NVP-2

SKU T16363-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 80 CAD through 1,557 CAD

Products Details

Product Description

– NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).

Web ID

– T16363

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H37ClN6O2

Citations

– 1. Shan X, Jiang R, Gou D, et al.Identification of a diketopiperazine‐based O‐GlcNAc transferase inhibitor sensitizing hepatocellular carcinoma to CDK9 inhibition.The FEBS Journal.2023 2. Wang J, Wen Y, Zhang Y, et al.An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.Journal of Advanced Research.2023

References

– Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.Mol Cell. 2017 Jul 6;67(1):5-18.e19.

CAS Number

– 1263373-43-8

Molecular Weight

– C27H37ClN6O2

Compound Purity

– 0.9976

SMILES

– COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1

Pathway

– Cell Cycle/Checkpoint|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mexenone
Mexenone Price range: 48 CAD through 157 CAD
1 mL * 10 mM (in DMSO)100 mg200 mg

1000 in stock

Select options
Phenytoin sodium
Phenytoin sodium Price range: 72 CAD through 85 CAD
1 g1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinoline Price range: 56 CAD through 77 CAD
100 mg200 mg

1000 in stock

Select options
Jedi2
Jedi2 Price range: 53 CAD through 1,117 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
AChE-IN-23
AChE-IN-23 Price range: 66 CAD through 150 CAD
100 mg200 mg50 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });