Numidargistat dihydrochloride
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Numidargistat dihydrochloride

SKU T10692-1 mg Category Brand:

Price range: 144 CAD through 2,976 CAD

Products Details

Product Description

– Numidargistat dihydrochloride (CB-1158 dihydrochloride) is an orally active and highly effective arginase (ARG1) inhibitor, an immuno-oncology agent that inhibits TGF-β2-induced subcapsular cataract by reducing the proliferation of lens epithelial cells (LEC) and decreasing the expression of fibronectin, α-SMA, collagen 1A1, and vimentin.

Web ID

– T10692

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C11H24BCl2N3O5

References

– Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.

Molecular Weight

– C11H24BCl2N3O5

Compound Purity

– 0.9949

SMILES

– O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl

Target

– Others

Pathway

– Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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