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Products Details
Product Description
– NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53[1].
Web ID
– HY-144105
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C12H10Cl2Sn
References
– [1]Chen S, et al. Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell. 2021;39(2):225-239.e8.
CAS Number
– 1135-99-5
Molecular Weight
– 343.82
SMILES
– Cl[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
