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Products Details
Product Description
– NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs)[1].
Web ID
– HY-112591
Shipping
– Room temperature
Molecular Formula
– C29H24N6O3
References
– [1]Dong S, et al. Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy. Sci Rep. 2023 Jul 22;13(1):11843.
CAS Number
– 906718-66-9
Molecular Weight
– 504.54
SMILES
– O=C(NC1=CC=C(/N=C2C=CN(C)C=C2)C=C1)C3=CC=C(/N=C4C=CN(C)C5=C4C=C([N+]([O-])=O)C=C5)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;HIV;Wnt
Pathway
– Anti-infection;Apoptosis;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
