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Products Details
Product Description
– NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].
Web ID
– HY-19539
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H10N2O6S2
References
– [1]Evelyn CR, et al. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chem Biol. 2014;21(12):1618-1628.
CAS Number
– 909197-38-2
Molecular Weight
– 438.43
SMILES
– O=C1/C(C(C2=CC=CC=C2O1)=O)=CN3C(S/C(C3=O)=CC4=CC=C([N+]([O-])=O)C=C4)=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
