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NSC-658497
Products Details
Product Description
– NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].
Web ID
– HY-19539
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H10N2O6S2
References
– [1]Evelyn CR, et al. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chem Biol. 2014;21(12):1618-1628.
CAS Number
– 909197-38-2
Molecular Weight
– 438.43
SMILES
– O=C1/C(C(C2=CC=CC=C2O1)=O)=CN3C(S/C(C3=O)=CC4=CC=C([N+]([O-])=O)C=C4)=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
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