NSC-658497

SKU HY-19539-10mg Category Tags , ,

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Products Details

Product Description

– NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].

Web ID

– HY-19539

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C20H10N2O6S2

References

– [1]Evelyn CR, et al. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chem Biol. 2014;21(12):1618-1628.

CAS Number

– 909197-38-2

Molecular Weight

– 438.43

SMILES

– O=C1/C(C(C2=CC=CC=C2O1)=O)=CN3C(S/C(C3=O)=CC4=CC=C([N+]([O-])=O)C=C4)=S

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Ras

Pathway

– GPCR/G Protein

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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