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NS1643
$46 – $1,155
Products Details
Product Description
– NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2].
Web ID
– HY-16916
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C15H10F6N2O3
References
– [1]Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11.|[2]Breuer EK, et al. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10(3):180.
CAS Number
– 448895-37-2
Molecular Weight
– 380.24
Compound Purity
– 99.14
SMILES
– O=C(NC1=C(O)C=CC(C(F)(F)F)=C1)NC2=C(O)C=CC(C(F)(F)F)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Autophagy;Potassium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
