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Products Details
Product Description
– NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells[1].
Web ID
– HY-156425
Shipping
– Room temperature
Molecular Formula
– C25H25N7O3
References
– [1]Jie Zang, et al.Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. J Med Chem. 2023 Oct 19.
CAS Number
– 2648709-79-7
Molecular Weight
– 471.51
SMILES
– NC1=NC2=CC=C(C=C2C=C1)OCC3=CN(N=N3)CCOCCOC4=CC=C5N=C(C=CC5=C4)N
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NADPH Oxidase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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