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Norepinephrine (bitartrate monohydrate)
$65 – $310
Products Details
Product Description
– Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].
Web ID
– HY-13715B
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H19NO10
Citations
– Br J Pharmacol. 2020 Aug;177(15):3389-3402. |Cell Rep. 2019 Dec 3;29(10):2936-2943.e4. |J Nutr Biochem. 2018 May 1;58:110-118.|Leiden University. Institute of Biology Leiden (IBL) , Faculty of Science.|Neuroscience. 2019 Mar 1;401:59-72. |Research Square Preprint. 2021 Aug.|Theranostics. 2022 Jun 6;12(10):4718-4733.|ACS Nano. 2022 Aug 23;16(8):12553-12568.|Biochem Biophys Res Commun. 2023 Mar 24;657:108-118.|bioRxiv. 2023 Oct 13.|Cell Death Dis. 2020 Aug 18;11(8):644.|Cell Mol Immunol. 2023 Jan 5.|Cell Rep Med. 2023 May 24;101061.|Eur J Pharmacol. 2022 May 12;175022.|Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.|Gene. 2023 Aug 31;147753.|Int J Mol Sci. 2022, 23(20), 12420.|J Am Heart Assoc. 2019 Jan 8;8(1):e009871.|J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227.|Nat Commun. 2022 Jul 25;13(1):4278.|Neurochem Int. 2020 Dec 16;104942.|Sci Rep. 2022 Jun 15;12(1):9936.|SSRN. 2023 May 8.|Cardiovasc Res. 2018 Feb 1;114(2):300-311. |FASEB J. 2020 Nov;34(11):14892-14904.
References
– [1]Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36.|[2]Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579.|[3]Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60.|[4]MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200.
CAS Number
– 108341-18-0
Molecular Weight
– 337.28
Compound Purity
– 99.75
SMILES
– OC1=CC=C([C@@H](O)CN)C=C1O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : ≥ 30 mg/mL|H2O : 50 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Autophagy;Endogenous Metabolite
Isoform
– Human Endogenous Metabolite;Microbial Metabolite;α adrenergic receptor;β adrenergic receptor
Pathway
– Autophagy;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
